Dermatopathology.pdf

LANDES

BIOSCIENCE

a d e m e c u

Dermatopathology

Ramón L. Sánchez

Sharon S. Raimer

vademecum

Dermatopathology

Ramón L. Sánchez, M.D.

The University of Texas Medical Branch at Galveston

Galveston, Texas, U.S.A.

Sharon S. Raimer, M.D.

The University of Texas Medical Branch at Galveston

Galveston, Texas, U.S.A.

G EORGETOWN , T EXAS

U.S.A.

L A N D E S

B I O S C I E N C E

VADEMECUM

Dermatopathology

LANDES BIOSCIENCE

Georgetown, Texas, U.S.A.

No part of this book may be reproduced or transmitted in any form or by any

means, electronic or mechanical, including photocopy, recording, or any

information storage and retrieval system, without permission in writing from the

publisher.

Printed in the U.S.A.

Please address all inquiries to the Publisher:

Landes Bioscience, 810 S. Church Street, Georgetown, Texas, U.S.A. 78626

Phone: 512/ 863 7762; FAX: 512/ 863 0081

ISBN: 1-57059-496-1

Library of Congress Cataloging-in-Publication Data

Dermatopathology / [edited by] Ramón Sánchez, Sharon Raimer.

p.;cm.--(Vademecum)

Includes index.

ISBN 1-57059-496-1

1. Skin--Diseases-Handbooks, manuals, etc. I. Sanchez, Ramon L. II. Raimer,

Sharon. III. Series.

[DNLM: 1. Skin Diseases--pathology. WR 140 D435172 2001]

RL96.D476 2001

616.5--dc21

01-042377

While the authors, editors, sponsor and publisher believe that drug selection and dosage and

the specifications and usage of equipment and devices, as set forth in this book, are in accord

with current recommendations and practice at the time of publication, they make no

warranty, expressed or implied, with respect to material described in this book. In view of the

ongoing research, equipment development, changes in governmental regulations and the

rapid accumulation of information relating to the biomedical sciences, the reader is urged to

carefully review and evaluate the information provided herein.

Dedication

To the students, residents and fellows through whom we learn so much in

the process of teaching.

To our families, always supportive of our endeavors.

Contents

1. Hyperkeratosis and Parakeratosis ..................................... 1

Gina Harney

Ichthyosis Vulgaris ...................................................................................... 1

X-Linked Ichthyosis .................................................................................... 1

Lamellar Ichthyosis ..................................................................................... 2

Palmoplantar Keratoderma ......................................................................... 3

Pachyonychia Congenita ............................................................................. 3

Flegel’s Disease (Hyperkeratosis Lenticularis Perstans) ................................. 3

Vitamin A Deficiency (Phrynoderma) ......................................................... 4

Confluent Parakeratosis .............................................................................. 5

Parakeratosis: Columnar or Focal ................................................................ 8

2. Acanthosis ....................................................................... 13

Marcia Driscoll

Regular Acanthosis .................................................................................... 13

Irregular Acanthosis .................................................................................. 14

Lacelike Acanthosis ................................................................................... 17

3. Papillomatosis, Atrophy and Alterations

of the Granular Layer ...................................................... 20

Gayle S. Westhoven

Verruca/Epidermodysplasia Verruciformis ................................................. 20

Nevus Sebaceous (Organoid Hamartoma) ................................................ 21

Linear (Verrucous) Epidermal Nevus ........................................................ 24

Acrokeratosis Verruciformis of Hopf ......................................................... 24

Degos’ Disease (Malignant Atrophic Papulosis) ......................................... 26

Striae Distensae ......................................................................................... 26

Radiation Dermatitis, Late ........................................................................ 27

Bullous Congenital Ichthyosiform Erythroderma ...................................... 27

Epidermolytic Keratosis Palmaris et Plantaris ............................................ 28

Isolated and Disseminated Epidermolytic Acanthoma ............................... 28

4. Spongiosis, Exocytosis and Acantholysis ......................... 29

Ramón L. Sánchez and Sharon S. Raimer

Subacute dermatitis ................................................................................... 29

Acute dermatitis ........................................................................................ 29

Oral White Sponge Nevus ........................................................................ 31

Leukoedema of the Oral Mucosa .............................................................. 31

Oral Focal Epithelial Hyperplasia .............................................................. 32

Oral Hairy Leukoplakia ............................................................................ 33

Pityriasis Lichenoides, Acuta and Chronica ............................................... 33

Actinic Reticuloid ..................................................................................... 35

Pemphigus Vulgaris ................................................................................... 35

Pemphigus Vegetans .................................................................................. 37

Pemphigus Foliaceous ............................................................................... 39

Pemphigus Erythematosus ........................................................................ 39

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