Chiral Separation Techniques A Practical Approach 2nd Edition (G. Subramanian).pdf

Chiral Separation Techniques: A Practical Approach, Second, completely revised and updated edition

Edited by G. Subramanian

ISBNs: 3-527-29875-4 (Hardcover); 3-527-60036-1 (Electronic)

Edited by

G. Subramanian

Chiral

Separation Techniques

Chiral

Separation Techniques

A Practical Approach

Second, completely revised and

updated edition

Edited by

G. Subramanian

Weinheim · Chichester · New York · Toronto · Brisbane · Singapore

Chiral Separation Techniques: A Practical Approach, Second, completely revised and updated edition

Edited by G. Subramanian

ISBNs: 3-527-29875-4 (Hardcover); 3-527-60036-1 (Electronic)

Chiral Separation Techniques: A Practical Approach, Second, completely revised and updated edition

Edited by G. Subramanian

ISBNs: 3-527-29875-4 (Hardcover); 3-527-60036-1 (Electronic)

Dr. Ganapathy Subramanian

60B Jubilee Road

Littlebourne

Canterbury

Kent CT3 1TP, UK

This book was carefully produced. Nevertheless, authors, editor, and publisher do not warrant

the information contained therein to be free of errors. Readers are advised to keep in mind that

statements, data, illustrations, procedural details or other items may inadvertently be inaccurate.

Library of Congress Card No. applied for

A catalogue record for this book is available from the British Library

Die Deutsche Bibliothek – CIP Cataloguing-in-Publication-Data

A catalogue record for this publication is available from Die Deutsche Bibliothek

ISBN 3-527-29875-4

Printed on acid-free paper.

reproduced in any form – by photoprinting, microfilm, or any other means – nor transmitted or

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sidered unprotected by law.

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Printed in the Federal Republic of Germany.

Chiral Separation Techniques: A Practical Approach, Second, completely revised and updated edition

Edited by G. Subramanian

ISBNs: 3-527-29875-4 (Hardcover); 3-527-60036-1 (Electronic)

Preface

During the past two decades there has been intense interest in the development and

application of chiral chromatographic methods, particularly in the pharmaceutical

industries. This is driven both by desire to develop and exploit “good science” and

by the increasing pressure by regulatory authorities over the past ten years against

the marketing of racemic mixtures. The regulation of chiral drug provides a good

demonstration of the mutual relationship between progress in scientific methodology

and regulatory guidelines. It has also provided a common platform in establishing

good understanding between international regulatory authorities and pharamceutical

industries, leading to a consensus in recognition of the global nature of pharmaceu-

tical development. This has provided a great challenge for the industries to seek

techniques that are efficient, economical and easy to apply, in the manufacture of

enantiopure products.

The versatility of chiral stationary phases and its effecitve application in both ana-

lytical and large-scale enantioseparation has been discussed in the earlier book ‘ A

Practical Approach to Chiral Separation by Liquid Chromatography ’ (Ed. G. Sub-

ramanian, VCH 1994). This book aims to bring to the forefront the current develop-

ment and sucessful application chiral separation techniques, thereby providing an

insight to researchers, analytical and industrial chemists, allowing a choice of

methodology from the entire spectrum of available techniques.

I am indebted to the leading international group of contributors, who have agreed

to share their knowlegde and experience. Each chapter represents an overview of its

chosen topic. Chapter 1 provider an overview of techniques in preparative chiral sep-

aration, while Chapter 2 provides an account on method development and optimisa-

tion of enantiomer separation using macrocyclic glycopeptide chiral stationary

phase. Combinatorial approach and chirabase applications are discussed in Chapters

3 and 4. Chapter 5 details the development of membranes for chiral separation, while

Chapter 6 gives an overview of implanting techniques for enantiopurification. Non

chromatographic solid-phase purification of enantiomers is explained in Chapter

7, and Chapter 8 discusses modeling and simulation of SMB and its application in

enantioseparation. A perspective on cGMP compliance for preparative chiral chro-

matography in discussed Chapter 9, and Chapter 10 provides an account of elec-

trophoretically driven preparative chiral separation and sub- and supercritical fluid

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