Jones C.J., Thornback J.R. Medicinal Applications of Coordination Chemistry (RSC, 2007)(0854045961).pdf

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134306549 UNPDF
MedicinalApplicationsofCoordinationChemistry
MedicinalApplicationsof
CoordinationChemistry
ChrisJones
SchoolofChemistry,UniversityofBirmingham,UK
andSchoolofChemistry,TheUniversityofManchester,UK
JohnThornback
MassTagTechnologiesLtd,Oxford,UK
134306549.001.png
CoverimagereproducedbypermissionofMarkWoodsfromDaltonTrans.,2005,
3829–3837.
ISBN:978-0-85404-596-9
AcataloguerecordforthisbookisavailablefromtheBritishLibrary
r TheRoyalSocietyofChemistry2007
Allrightsreserved
Apartfromfairdealingforthepurposesofresearchfornon-commercialpurposesorfor
privatestudy,criticismorreview,aspermittedundertheCopyright,DesignsandPatents
Act1988andtheCopyrightandRelatedRightsRegulations2003,thispublicationmaynot
bereproduced,storedortransmitted,inanyformorbyanymeans,withouttheprior
permissioninwritingofTheRoyalSocietyofChemistry,orinthecaseofreproductionin
accordancewiththetermsoflicencesissuedbytheCopyrightLicensingAgencyintheUK,
orinaccordancewiththetermsofthelicencesissuedbytheappropriateReproduction
RightsOrganizationoutsidetheUK.Enquiriesconcerningreproductionoutsidetheterms
statedhereshouldbesenttoTheRoyalSocietyofChemistryattheaddressprintedonthis
page.
PublishedbyTheRoyalSocietyofChemistry,
ThomasGrahamHouse,SciencePark,MiltonRoad,
CambridgeCB40WF,UK
RegisteredCharityNumber207890
Forfurtherinformationseeourwebsiteatwww.rsc.org
TypesetbyMacmillanIndiaLtd,Bangalore,India
PrintedbyHenryLingsLtd,Dorchester,Dorset,UK
Preface
Duringthelaterpartofthe20thcentury,pharmaceuticalcompoundscontain-
ingmetalsbegantoplayanincreasinglyimportantroˆleinmedicine.In
particular,thediscoveryofplatinumanticancerdrugsandtheappearanceof
organspecificdiagnostic-imagingagentscontainingtechnetiumwerepromi-
nentdevelopmentsthathavestimulatedfurtherinterestinso-calledmetallo-
pharmaceuticals.Today,themetallopharmaceuticalsindustryhasaglobal
marketmeasuredinbillionsofpoundsandhaswell-establishedapplicationsin
bothdiagnosticandtherapeuticmedicine.
Theaimofthisbookistoreviewthediagnosticandtherapeuticapplications
ofselectedmetallicelementsandconsiderthechemistryunderlyingtheformu-
lationofmetallopharmaceuticals.Inordertodothisitisnecessarytoassume
somebasicunderstandingofthechemicalbehaviourofmetalsand,inpartic-
ular,theircoordinationchemistry.Averybriefintroductiontocoordination
chemistryisalsopresentedforthebenefitofthoseunfamiliarwiththisaspectof
chemistry.Thelevelofpresentationofthissectionisdesignedforageneralbut
scientificallyliterateaudience,someofwhommayhaveonlyarudimentary
knowledgeofchemistry.Itishopedthetextwillbehelpfultopharmacistsas
wellastocliniciansandmedicalresearchersusingmetalcontainingdrugsina
clinicalenvironment.However,itisalsohopedthatthebookmightalsoserve
asanintroductorytextofinteresttochemistrystudentswishingtolearnabout
anaspectoftheirsubjectwithinanappliedcontext,ratherthanjustasasubject
initsownright.
Thediscussionofmedicinalapplicationsfocusesonthecoordinationchem-
istryofwhatareknownasthetransitionalelements,particularlyvanadium,
manganese,technetium,rutheniumrhodium,platinum,goldandgadolinium.
Compoundscontainingmetalsofthistypearethemostamenabletomanip-
ulationthroughchemicaldesignsothatcoordinationchemistryplaysasignif-
icantroˆleinthedevelopmentofmetallopharmaceuticalsinvolvingthesemetals.
Theso-calledmaingroupmetals(e.g.gallium,indium,tin,lead,bismuth)are,
forthemostpart,notincludedthoughsomeoftheirapplicationsaremen-
tioned.Theseelementsofferlessscopefortheapplicationofcoordination
chemistryinproductdevelopmentastheircompoundstypicallybreakdown
quicklyinvivotransferringthemetaltobiologicalbindingagentsandafate
largelybeyondthechemistsdirectcontrol.
Thefirstintroductorychapteraimstosetthescenewithabriefhistorical
reviewandaconsiderationofsomegeneralaspectsoftheuseofchemical
substancesinmedicine.Thesecondchapterprovidesaconcisedescriptionof
v

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