Understanding Mass Spectra (Wiley).pdf

UNDERSTANDING

MASS SPECTRA

Second Edition

UNDERSTANDING

MASS SPECTRA:

A Basic Approach

SECOND EDITION

R. Martin Smith

A JOHN WILEY & SONS, INC., PUBLICATION

Published by John Wiley & Sons, Inc., Hoboken, New Jersey.

Published simultaneously in Canada.

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Library of Congress Cataloging-in-Publication Data:

Smith, R. Martin.

Understanding mass spectra : a basic approach. – 2nd ed. / R. Martin Smith.

p. cm.

Includes bibliographical references and index.

ISBN 0-471-42949-X (acid-free paper)

1. Mass Spectrometry. I. Title.

QD96 .M3S65 2005

543 0 .0873–dc22

2004003683

Printed in the United States of America

10987654321

CONTENTS

Preface to the Second Edition

Acknowledgments

Abbreviations and Notations Used in This Book

xvii

1 Instrumentation

1.1. Introduction / 1

1.1.1. Overview / 1

1.1.2. Sample Introduction / 3

1.2. Ionization Source / 4

1.2.1. Electron Ionization Source / 5

1.2.2. Chemical Ionization / 8

1.2.3. Other Ionization Methods / 9

1.2.3.1. Electrospray Ionization / 9

1.2.3.2. Desorption Ionization / 12

1.3. m/z Analysis / 13

1.3.1. Time-of-Flight (TOF) / 13

1.3.2. Magnetic Sector / 15

1.3.3. Transmission Quadrupole / 17

1.3.3.1. Selected Ion Monitoring (SIM) / 21

1.3.4. Quadrupole Ion Trap (QIT) / 22

1.3.5. Other Types of Mass Analysis / 24

1.3.5.1. Mass Spectrometry/Mass

Spectrometry(MS/MS) / 24

1.3.5.2. Accurate m = z Analysis / 26

1.3.6. Spectral Skewing / 26

1.4. Ion Detection / 30

1.4.1. Electron Multiplier / 32

1.4.2. Photomultiplier Detector / 33

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