TRANSFORMING GROWTH FACTOR-B IN CANCER THERAPY, VOL. 2.pdf

TRANSFORMING GROWTH FACTOR-B

IN CANCER THERAPY, VOLUME II

CANCER DRUG DISCOVERY AND DEVELOPMENT

Beverly A. Teicher, PhD, SERIES EDITOR

Cancer Chemoprevention, Volume 2: Strategies for

Cancer Chemoprevention, edited by Gary J. Kelloff,

Ernest T. Hawk, and Caroline C. Sigman, 2005

Death Receptors in Cancer Therapy, edited by Wafik S.

El-Deiry, 2005

Cancer Chemoprevention, Volume 1: Promising Cancer

Chemopreventive Agents, edited by Gary J. Kelloff,

Ernest T. Hawk, and Caroline C. Sigman, 2004

Proteasome Inhibitors in Cancer Therapy, edited by

Julian Adams, 2004

Nucleic Acid Therapeutics in Cancer, edited by Alan M.

Gewirtz, 2004

DNA Repair in Cancer Therapy, edited by Lawrence C.

Panasci and Moulay A. Alaoui-Jamali, 2004

Hematopoietic Growth Factors in Oncology: Basic

Science and Clinical Therapeutics, edited by

George Morstyn, MaryAnn Foote, and Graham J.

Lieschke, 2004

Handbook

Checkpoint Responses in Cancer Therapy, edited by

Wei Dai, 2008

Cancer Proteomics: From Bench to Bedside,

edited by

Sayed S. Daoud, 2008

Transforming Growth Factor-B in Cancer Therapy,

Volume II: Cancer Treatment and Therapy, edited

by Sonia Jakowlew, 2008

Transforming Growth Factor-B in Cancer Therapy,

Volume 1: Basic and Clinical Biology, edited by

Sonia Jakowlew, 2008

Microtubule

Targets

Cancer

Therapy,

edited by

Antonio T. Fojo, 2008

Antiangiogenic Agents in Cancer Therapy, Second

Edition, edited by Beverly A. Teicher and Lee M.

Ellis, 2007

Apoptosis and Senescence in Cancer Chemotherapy and

Radiotherapy, Second Edition, edited by David A.

Gerwitz; Shawn Edan Holtz, and Steven Grant, 2007

Molecular Targeting in Oncology, edited by Howard L.

Kaufman, Scott Wadler, and Karen Antman, 2007

Anticancer

Pharmacokinetics

and

Pharmacodynamics, edited by

William

Figg

Vivo

Imaging

of Cancer

Therapy,

and Howard L. McLeod, 2004

Anticancer Drug Development Guide: Preclinical

Screening, Clinical Trials, and Approval, Second

Edition, edited by Beverly A. Teicher and Paul A.

Andrews, 2004

Handbook of Cancer Vaccines, edited by Michael A.

Morse, Timothy M. Clay, and Kim H. Lyerly, 2004

Drug Delivery Systems in Cancer Therapy, edited by

Dennis M. Brown, 2003

Oncogene-Directed Therapies, edited by Janusz Rak, 2003

Cell

edited

Anthony F. Shields and Patricia Price, 2007

Cytokines in the Genesis and Treatment ofCancer, edited

Michael A.

Caligiuri,

Michael

T. Lotze,

and

Frances R. Balkwill, 2007

Regional Cancer Therapy, edited by Peter M. Schlag and

Ulrike Stein, 2007

Gene

Therapy for

Cancer,

edited by

Kelly

Hunt,

Stephan A.

Vorburger,

and Stephen

Swisher,

2007

Deoxynucleoside Analogs in Cancer Therapy, edited by

Godefridus J. Peters, 2006

Cancer Drug Resistance, edited by Beverly A. Teicher, 2006

Histone

Cycle

Inhibitors

Cancer

Therapy:

Current

Strategies,

edited

Antonio

Giordano

and

Kenneth J. Soprano, 2003

Chemoradiation

Deacetylases:

Cancer

Therapy,

Transcriptional

Regulation

and

edited by

Hak

Other

Cellular Functions,

edited by Eric Verdin,

Choy, 2003

Fluoropyrimidines in Cancer Therapy, edited by Youcef

M. Rustum, 2003

Targetsfor Cancer Chemotherapy: Transcription Factors

and Other Nuclear Proteins, edited by Nicholas

B. La Thangue and Lan R. Bandara, 2002

Tumor Targeting in Cancer Therapy, edited by Michel

Page, 2002

Hormone Therapy in Breast and Prostate Cancer, edited

by v: Craig Jordan and Barrington J. A. Furr, 2002

Tumor Models in Cancer Research, edited by Beverly A.

Teicher, 2002

Tumor Suppressor Genes in Human Cancer, edited by

David E. Fisher, 2001

Matrix M etalloproteinase Inhibitors in Cancer Therapy,

edited

2006

Immunotherapy ofCancer, edited by Mary L. Disis, 2006

Biomarkers in Breast Cancer: Molecular Diagnostics

for Predicting and Monitoring Therapeutic Effect,

edited by

Giampietro

Gasparini

and

Daniel F.

Hayes, 2006

Protein

Tyrosine Kinases:

From

Inhibitors

Useful

Drugs,

edited

Doriana

Fabbro

and

Frank

McCormick, 2005

Bone Metastasis: Experimental and Clinical Therapeutics,

edited by Gurmit Singh and Shafaat A. Rabbani,

2005

The Oncogenomics Handbook, edited by William J.

LaRochelle and Richard A. Shimkets, 2005

Camptothecins

Cancer

Therapy,

edited

Neil

Clendeninn

and

Krzysztof

Thomas G. Burke and Val R. Adams, 2005

Combination Cancer Therapy: Modulators and

Potentiators, edited by Gary K. Schwartz, 2005

Appelt, 2001

Farnesyltransferase Inhibitors in Cancer, edited by Said

M. Sebti and Andrew D. Hamilton, 2001

TRANSFORMING

GROWTH FACTOR-P

IN CANCER THERAPY,

VOLUME II

CANCER TREATMENT AND THERAPY

Edited by

SONIA B. JAKOWLE~ PhD

Cancer Training Branch, Office ofCenters, Training and Resources,

National Cancer Institute, Bethesda, MD

Foreword by

CARL-HENRIK HELDIN, PhD

Ludwig Institute for Cancer Research,

Uppsala University, Uppsala, Sweden

~\I', H

umana

ress

-"1\::

999 Riverview Drive, Suite 208

Totowa, New Jersey 07512

www.humanapress.com

by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise without written permission

from the Publisher.

The content and opinions expressed in this book are the sole work of the authors and editors, who have warranted due

diligence in the creation and issuance of their work. The publisher, editors, and authors are not responsible for errors

or omissions or for any consequences arising from the information or opinions presented in this book and make no

warranty, express or implied, with respect to its contents.

Due diligence has been taken by the publishers, editors, and authors of this book to assure the accuracy of the informa-

tion published and to describe generally accepted practices. The contributors herein have carefully checked to ensure that

the drug selections and dosages set forth in this text are accurate and in accord with the standards accepted at the time

of publication. Notwithstanding, since new research, changes in government regulations, and knowledge from clinical

experience relating to drug therapy and drug reactions constantly occur, the reader is advised to check the product

information provided by the manufacturer of each drug for any change in dosages or for additional warnings and contra-

indications. This is of utmost importance when the recommended drug herein is a new or infrequently used drug. It is

the responsibility of the treating physician to determine dosages and treatment strategies for individual patients. Further,

it is the responsibility of the health care provider to ascertain the Food and Drug Administration status of each drug

or device used in their clinical practice. The publishers, editors, and authors are not responsible for errors or omissions or

for any consequences from the application of the information presented in this book and make no warranty, express

or implied, with respect to the contents in this publication.

This publication is printed on acid-free paper. e

ANSI Z39.48-1984 (American National Standards Institute) Permanence of Paper for Printed Library Materials.

Production Editor: Michele Seugling

Cover design by Nancy Fallatt

For additional copies, pricing for bulk purchases, and/or information about other Humana titles, contact Humana

at the above address or at any of the following numbers: Tel: 973-256-1699; Fax: 973-256-8341; or visit our Website:

http://humanapress.com

Photocopy Authorization Policy:

Authorization to photocopy items for internal or personal use, or the internal or personal use of specific clients, is granted

by Humana Press, provided that the base fee of US $30.00 per copy is paid directly to the Copyright Clearance Center

at 222 Rosewood Drive, Danvers, MA 01923. For those organizations that have been granted a photocopy license from

the CCC, a separate system of payment has been arranged and is acceptable to Humana Press. The fee code for users of

the Transactional Reporting Service is: [978-1-58829-715-0/08 $30.00].

Printed in the United States of America.

e-ISBN: 978-1-59745-293-9

Library of Congress Control Number: 2007931768

Plik z chomika:

Inne pliki z tego folderu:

Inne foldery tego chomika: