Principles of Protein X-Ray Crystallography 3rd ed - J. Drenth (Springer, 2007) WW.pdf

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Principles of Protein X-Ray
Crystallography
Jan Drenth
Principles of Protein X-Ray
Crystallography
Third Edition
With Major Contribution from
Jeroen Mesters
University of L ubeck, Germany
895245003.002.png
Jan Drenth
Laboratory of Biophysical Chemistry
University of Groningen
Nyenborgh 4
9747 AG Groningen
The Netherlands
j.drenth@rug.nl
Cover illustration : Courtesy of Adrian R. Ferre-D’Amare and Stephen K. Burley, The Rockefeller
University. The four-
-helix bundle moiety of transcription factor Max. Reproduced with permission
from Nature 363:38–45 (1993).
Library of Congress Control Number: 2006926449
ISBN-10: 0-387-33334-7
e-ISBN-10: 0-387-33746-6
ISBN-13: 978-0-387-33334-2
e-ISBN-13: 978-0-387-33746-3
Printed on acid-free paper.
2007, 1999, 1994 Springer Science+Business Media, LLC
All rights reserved. This work may not be translated or copied in whole or in part without the written
permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York,
NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use
in connection with any form of information storage and retrieval, electronic adaptation, computer
software, or by similar or dissimilar methodology now known or hereafter developed is forbidden.
The use in this publication of trade names, trademarks, service marks, and similar terms, even if they
are not identified as such, is not to be taken as an expression of opinion as to whether or not they are
subject to proprietary rights.
C
987654321
springer.com
Preface to the Third Edition
In the 7 years since the publication of the previous edition, protein X-ray crys-
tallography has made rapid progress. This was, to a large extent, triggered by the
sudden growth of interest in structural genomics. Impressive technological ad-
vances facilitated this development. It required updating Chapter 2 on Sources and
Detectors.
It is no longer an exception to collect a full dataset in a few minutes and to solve
the structure in hours. However, one bottleneck remains and that is the growth
of quality crystals. Although accelerated by robotic systems, it is still a trial-and-
error process. For the benefit of the novice in crystallization, a chapter on “Practical
Protein Crystallization” written by Dr. Jeroen R. Mesters has been added.
Another addition is a section on single-wavelength anomalous diffraction. This
technique has gained much popularity in recent years, especially in the high-
throughput field. Also SHELXD, a dual-space direct method for substructure de-
termination, equally useful as SnB, has now been added to Chapter 11 on Direct
Methods.
We are indebted to many colleagues who in some way or another assisted us
in the preparation of this edition. Among them are Thomas Barends, Zbigniew
Dauter, Rolf Hilgenfeld, Ankie Terwisscha van Scheltinga, Bram Schierbeek
George Sheldrick, and Simon Tulloch. Jan Drenth is especially grateful to Bauke
Dijkstra for the generous hospitality in his laboratory.
Jeroen Mesters
Jan Drenth
v

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