Science - October 11 2013.pdf

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CONTENTS

EDITORIAL

161

BOOKS ET AL.

195

Marcia McNutt

Artemisia annua

D. G. Dalrymple, reviewed by W. Lawley et al.

NEWS OF THE WEEK

172

196

D. E. Hough, reviewed by R. S. Mathis

NEWS & ANALYSIS

175

176

177

178

POLICY FORUM

197

B. Wilcken

>> Podcast

PERSPECTIVES

200

page 183

B. Bae and C. A. Walsh

179

201

M. Heyde

>> Report p. 224

181

>> Report p. 257 Express Report

by R. Bollongino

202

ﬁ

Y. Fainman and G. Porter

182

203

B. D. Simons

>> Research Article p. 212

NEWS FOCUS

183

205

E. S. Bernhardt

>> Report p. 247

>> Podcast

186

206

R. C. Hardison and G. A. Blobel

>> Report p. 253

LETTERS

191

S.-W. Lee et al.

K. L. Rising and N. Lurie

D. H. Johnson and R. D. Cook

D. E. Chubin

207

S. M. Sagan and P. Sarnow

>> Reports pp. 231 and 235

page 200

CONTENTS continued >>

ON THE WEB THIS WEEK

>> Science Podcast

Listen to stories about gaps in the evidence

for newborn screenings, the formation of the

Moon, removing nitrogen from lakes, and more.

>> Find More Online

Check out Science Express, our podcast,

videos, daily news, our research journals, and

Science Careers at www.sciencemag.org .

193

COVER

False-colored scanning electron micrograph of erythrocytes

(diameter ~7 micrometers). Sickle cell disease results from an

inherited defect of adult hemoglobin, the oxygen-carrying

metalloprotein constituent of erythrocytes. Common genetic variation

associated with sickle cell disease severity modulates an adult-stage

erythroid enhancer element of the BCL11A gene. Disruption of this

element could ameliorate the disease by reestablishing expression

of fetal hemoglobin. See pages 206 and 253.

Image: Dennis Kunkel Microscopy, Inc./Visuals Unlimited, Inc.

DEPARTMENTS

159 Science

163

170

Science

265

266

Science

www.sciencemag.org SCIENCE VOL 342 11 OCTOBER 2013

155

Published by AAAS

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CONTENTS

REVIEW

210

231

Y. Li et al.

E. L. Pearce et al.

Review Summary; for full text:

http://dx.doi.org/10.1126/science.1242454

235

P. V. Maillard et al.

>> Perspective p. 207

RESEARCH ARTICLES

211

D. Jukam et al.

ﬁ

Research Article Summary; for full text:

http://dx.doi.org/10.1126/science.1238016

239

J.-B. Vannier et al.

212

ﬁ

A. E. Shyer et al.

>> Perspective p. 203

243

ﬂ

Y. Shi et al.

ﬂ

pages 203 & 212

REPORTS

218

247

ﬂ

J. C. Finlay et al.

>> Perspective p. 205; Podcast

J. Farihi et al.

220

D. Milathianaki et al.

250

B. T. Ho et al.

224

P. Y. Huang et al.

>> Perspective p. 201

pages 201 & 224

253

BCL11A

D. E. Bauer et al.

N , A S

>> Perspective p. 206

β

227

S. French et al.

ﬁ

257

G. Brandt et al.

ﬁ

>> News story p. 181

N , J

) E , M

SCIENCE (ISSN 0036-8075) is published weekly on Friday, except the last week in December, by the American Association for the Advancement of Science, 1200

New York Avenue, NW, Washington, DC 20005. ﬁ

Printed in the U.S.A

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Single-copy sales: Authorization to photocopy

ﬁ

Science Science Reader’s Guide to Periodical Literature

: O

www.sciencemag.org SCIENCE VOL 342 11 OCTOBER 2013

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Published by AAAS

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Farihi et al.

ﬁ

Sagan

SarnowLi et al.

Mail-

lard et al.

Mapping Mantle Mixing

ﬂ

ﬁ

French et al .

ﬁ

ﬂ

Shyer et

al .

Simons

ﬁ

ﬁ

ﬁ

Milathianaki et al.

ﬂ

ﬂ

Finlay et al .

Bernhardt

Brandt et al .

Huang et

al .Heyde

www.sciencemag.org SCIENCE VOL 342 11 OCTOBER 2013

159

Published by AAAS

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THIS WEEK IN SCIENCE

Additional summaries

ﬁ

Pearce et al .

ﬂ

ﬂ

ﬁ

ﬁ

ﬁ Shi et

al.

ﬁ

ﬁ

ﬂ ﬁ

ﬂ

Pseudomonas aeruginosa

Ho et

al.

ﬁ

Jukam et al .

ﬂ

ﬂ

ﬁ

BCL11A

Bauer et al .

Hardison and Blobel

BCL11A

BCL11A

Vannier et al .

: I T .

www.sciencemag.org SCIENCE VOL 342 11 OCTOBER 2013

159-b

Published by AAAS

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