USMLE Step1 Kaplan - biochemistry.pdf

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Biochemistry Notes
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USMLE' Step
1
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Biochemistry Notes
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*USMLEis a joint program of the Federation of State Medical Boards of the United States, Inc. and the National Board of Medical Examiners.
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@2002 Kaplan, Inc.
All rights reserved. No part of this book may be reproduced in any form, by photostat,
microfilm, xerography or any other means, or incorporated into any information
retrieval system, electronic or mechanical, without the written permission of Kaplan, Ine.
,
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Authorand ExecutiveEditor
Barbara Hansen, Ph.D.
Chair of Biochemistry Department
Kaplan Medical
Chicago, IL
Author
Lynne B. Jorde, Ph.D.
Professor and Associate Chairman
Department of Human Genetics
University of Utah Health Sciences Center
Salt Lake City, UT
Contributors
Roger Lane, Ph.D.
Associate Professor
University of South Alabama College of Medicine
Mobile, AL
Vernon Reichenbacher, Ph.D.
Associate Professor
Department of Biochemistry and Molecular Biology
Marshall University School of Medicine
Huntington, WV
ExecutiveDirectorof Curriculum
Richard Friedland, M.D.
Directorof PublishinandMedia
Michelle Covello
Directoof MedicaIllustration
Christine Schaar
ManagingEditor
Kathlyn McGreevy
ProductioEditor
Ruthie Nussbaum
ProductionArtist
Michael Wolff
CoverDesign
Joanna Myllo
CoverArt
Christine Schaar
Rich LaRocco
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Tableof Contents
Preface.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii
Section I: Molecular Biology and Biochemistry
Chapter 1: NucleicAcidStructurandOrganization.. . . . . . . . . . . . . . . . . . . 3
Chapter2: DNAReplicatioandRepair. . . . . .. . . . . . .. . . . . . .. .. .. . . . . 15
Chapter 3: TranscriptioandRNAProcessing.. . . . . . , . . . . . . . . . . . . . . . . 27
"
Chapter 4: The Genetic Code, MutationsandTranslation. . . . . . . . . . . . . . 43
Chapter 5: GenetiRegulation. .. . .. . . . . .. .. . . . . .. . .. . . . .. . .. . . . . 67
DNA.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81
Chapter 7: GenetiTesting. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 93
Chapter 8: Amino Acids, Proteins, andEnzymes.
. . . . . . . . . . . . . . . . . . . . . 117
Chapter9: Hormones.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 131
Chapter 10: Vitamins. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 143
Chapter 11: Overview of Energy Metabolism. . .. . . . .. .. . . .. . .. . .. . .. 153
Chapter 12: Glycolysis and Pyruvate Dehydrogenase. .. .. . . .. . .. . .. . .. 161
Chapter 13: Citric Acid Cycle and Oxidative Phosphorylation. . . . . . . . . . . . 179
Chapter 14: Glycogen, Gluconeogenesis and the Hexose
Monophosphate Shunt. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 191
Chapter 15: Lipid Synthesis and Storage.. . . .. .. . . . .. . . . . . .. .. .. . .. 207
iiietlical
v
Chapter 6: Recombinant
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