Predictive Toxicology in Drug Safety-Cambridge University Press (2010).pdf

This page intentionally left blank

Predictive toxicology in drug Safety

According to the Institute of Medicine and the U.S. Food and Drug

Administration, “developing new scientiic approaches to detecting,

understanding, predicting, and preventing adverse events” was a

critical path to the future of drug safety. This book brings together a

collection of state-of-the-art chapters, written by experts in the drug

safety ield. It provides information on the present knowledge of drug

side effects and their mitigation strategy during drug discovery, gives

guidance for risk assessment, and promotes evidence-based toxicol-

ogy. Each speciic area of toxicology relevant for drug discovery is dis-

cussed in detail, including theory, experimental approaches, and data

interpretation supported by comprehensive up-to-date references.

Many chapters provide fascinating case studies, which are of general

interest for those who have basic science training and are interested in

how chemicals interact with the human body.

Dr. Jinghai J. Xu is currently Director of Knowledge Discovery and

Knowledge Management at Merck & Company, Inc. Dr. Xu has won

numerous awards, including the Central Research Achievement Award

and Pizer Global Research & Development Award. His most recently

published book is Drug Eficacy, Safety, and Biologics Discovery: Emerging

Technologies and Tools (2009).

Dr. Laszlo Urban is currently Executive Director and Global Head

of Preclinical Safety Proiling at Novartis Institutes for Biomedical

Research. Dr. Urban has been actively involved in organizations such

as the European Neuropeptide Club, the Society for Biomolecular

Sciences, and the International Association for the Study of Pain. His

most recently published work is Hit and Lead Proiling: Identiication and

Optimization of Drug-Like Molecules (2009).

Predictive Toxicology in

Drug Safety

Edited by

Jinghai J. Xu

Merck & Company, Inc.

Laszlo Urban

Novartis Institutes for Biomedical Research