G Protein-Coupled Receptors as Drug Targets - R. Seifert, T. Wieland (Wiley, 2005) WW.pdf - książki - Bio Med 11 - bibiariel

G Protein-Coupled Receptors

as Drug Targets

Edited by

Roland Seifert, Thomas Wieland

Methods and Principles in Medicinal Chemistry

Edited by R. R. Mannhold, H. Kubinyi, G. Folkers

Editorial Board

H.-D. H¨ltje, H. Timmerman, J. Vacca, H. van de Waterbeemd, T. Wieland

Previous Volumes of this Series:

D. Smith, D. Walker,

H. van de Waterbeemd

H. van de Waterbeemd, H. Lennern¨s,

P. Artursson (eds.)

Pharmacokinetics and

Metabolism in Drug Design

Vol. 13

2001, ISBN 3-527-30197-6

Drug Bioavailability

Vol. 18

2003, ISBN 3-527-30438-X

H.-J. B¨hm, S. S. Abdel-Meguid (eds.)

Protein Crystallography

in Drug Discovery

Vol. 20

2004, ISBN 3-527-30678-1

T. Lenaguer (ed.)

Bioinformatics –

From Genomes to Drugs

Vol. 14

2002, ISBN 3-527-29988-2

Th. Dingermann, D. Steinhilber,

G. Folkers (eds.)

Molecular Biology

in Medicinal Chemistry

Vol. 21

2004, ISBN 3-527-30431-2

J. K. Seydel, M. Wiese

Drug-Membrane Interactions

Vol. 15

2002, ISBN 3-527-30427-4

O. Zerbe (ed.)

H. Kubinyi, G. M¨ller (eds.)

BioNMR in Drug Research

Vol. 16

2002, ISBN 3-527-30465-7

Chemogenomics in

Drug Discovery

Vol. 22

2004, ISBN 3-527-30987-X

P. Arloni, F. Alber (eds.)

Quantum Medicinal Chemistry

Vol. 17

2003, ISBN 3-527-30456-8

T. I. Oprea (ed.)

Chemoinformatics in Drug

Discovery

Vol. 23

2005, ISBN 3-527-30753-2

G Protein-Coupled Receptors

as Drug Targets

Analysis of Activation and

Constitutive Activity

Edited by

Roland Seifert and Thomas Wieland

Series Editors:

All books published by Wiley-VCH are carefully pro-

duced. Nevertheless, authors, editors, and publisher

do not warrant the information contained in these

books, including this book, to be free of errors. Rea-

ders are advised to keep in mind that statements, data,

illustrations, procedural details or other items may

inadvertently be inaccurate.

Prof. Dr. RaimundMannhold

Biomedical Research Center

Molecular Drug Research Group

Heinrich-Heine-Universit¨t

Universt¨tsstrasse 1

40225 D¨sseldorf

Germany

Raimund.mannhold@uni-duesseldorf.de

Library of Congress Card No.: Applied for.

British Library Cataloguing-in-Publication Data:

A catalogue record for this book is available

from the British Library.

Prof. Dr. HugoKubinyi

Donnersbergstrasse 9

67256 Weisenheim am Sand

Germany

kubinyi@t-online.de

Bibliographic information published by

Die Deutsche Bibliothek

Die Deutsche Bibliothek lists this publication in the

Deutsche Nationalbibliografie; detailed

bibliographic data is available in the Internet at

http://dnb.ddb.de

Prof. Dr. Gerd Folkers

Collegium Helveticum

STW/ETH Zentrum

8092 Z¨rich

Switzerland

folkers@collegium.ethz.ch

2005 WILEY-VCH Verlag

GmbH & Co. KGaA, Weinheim

other languages). No part of this book may be re-

produced in any form – by photoprinting, microfilm,

or any other means – nor transmitted

or translated into a machine language without written

permission from the publishers.

Volume Editors:

Prof. ThomasWieland

Institut f¨r Pharmakologie und Toxikologie

Fakult¨t f¨r Klinische Medizin Mannheim

Der Universit¨t Heidelberg

Maybachstraße 14-16

68169 Mannheim

Germany

thomas.wieland@urz.uni-heidelberg.de

Typesetting Mitterweger & Partner,

Kommunikationsgesellschaft mbH, Plankstadt

Printing Strauss GmbH, M¨rlenbach

Bookbinding

J. Sch¨ffer GmbH, Gr¨nstadt

Prof. Roland Seifert

Department of Pharmacology and Toxicology

University of Regensburg

Universit¨tsstraße 31

D-93053 Regensburg

Germany

roland.seifert@chemie.uni-regensburg.de

Printed in the Federal Republic of Germany

ISBN-13: 978-3-527-30819-4

ISBN-10: 3-527-30819-9

G Protein-Coupled Receptors as Drug Targets - R. Seifert, T. Wieland (Wiley, 2005) WW.pdf

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