Optimization in Drug Discovery - In Vitro Methods - Z. Yan, G. Caldwell (Humana, 2004) WW.pdf
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M E T H O D S I N P H A R M A C O L O G Y A N D T O X I C O L O G Y
Optimization
in Drug Discovery
Optimization
in Drug Discovery
In Vitro Methods
In Vitro Methods
Edited by
Edited by
Zhengyin Yan
Zhengyin Yan
Gary W. Caldwell
Gary W. Caldwell
Optimization in Drug Discovery
METHODS IN PHARMACOLOGY AND TOXICOLOGY
Y. J
AMES
K
ANG
, S
ERIES
E
DITOR
Optimization in Drug Discovery: In Vitro Methods, edited by
Zhengyin
Yan
and
Gary W. Caldwell,
2004
Cardiac Drug Development Guide, edited by
Michael K. Pugsley,
2003
Apoptosis Methods in Pharmacology and Toxicology: Approaches
to Measurement and Quantification, edited by
Myrtle A. Davis,
2002
Ion Channel Localization: Methods and Protocols, edited by
Anatoli
N. Lopatin
and
Colin G. Nichols,
2001
METHODS IN PHARMACOLOGY AND TOXICOLOGY
Optimization
in Drug Discovery
In Vitro Methods
Edited by
Zhengyin Yan,
PhD
Gary W. Caldwell,
PhD
Johnson & Johnson Pharmaceutical Research & Development
Spring House, PA
© 2004 Humana Press Inc.
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www.humanapress.com
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warranted due diligence in the creation and issuance of their work. The publisher, editors, and authors
are not responsible for errors or omissions or for any consequences arising from the information or
opinions presented in this book and make no warranty, express or implied, with respect to its contents.
Cover design by Patricia F. Cleary.
Production Editors: Jessica Jannicelli and Wendy Kopf.
Cover art: Figure 1 from Chapter 13, “In Vitro CYP Induction in Human Hepatocytes,” by Daniel R.
Mudra and Andrew Parkinson.
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Printed in the United States of America. 10 9 8 7 6 5 4 3 2 1
e-ISBN: 1-59259-800-5
Library of Congress Cataloging-in-Publication Data
Optimization in drug discovery : in vitro methods / edited by
Zhengyin Yan, Gary W. Caldwell.
p. ; cm. -- (Methods in pharmacology and toxicology)
Includes bibliographical references and index.
ISBN 1-58829-332-7 (alk. paper)
1. Pharmaceutical chemistry--Laboratory manuals. 2. Physical
biochemistry--Laboratory manuals. 3. Drugs--Testing--Laboratory
manuals.
[DNLM: 1. Drug Evaluation, Preclinical--methods. QV 771 O62
2004] I. Yan, Zhengyin. II. Caldwell, Gary, 1953- III. Series.
RS407.O66 2004
615'.19'0072--dc22
2004008395
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