Optimization in Drug Discovery - In Vitro Methods - Z. Yan, G. Caldwell (Humana, 2004) WW.pdf

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M E T H O D S I N P H A R M A C O L O G Y A N D T O X I C O L O G Y
Optimization
in Drug Discovery
Optimization
in Drug Discovery
In Vitro Methods
In Vitro Methods
Edited by
Edited by
Zhengyin Yan
Zhengyin Yan
Gary W. Caldwell
Gary W. Caldwell
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Optimization in Drug Discovery
METHODS IN PHARMACOLOGY AND TOXICOLOGY
Y. J AMES K ANG , S ERIES E DITOR
Optimization in Drug Discovery: In Vitro Methods, edited by Zhengyin
Yan and Gary W. Caldwell, 2004
Cardiac Drug Development Guide, edited by Michael K. Pugsley,
2003
Apoptosis Methods in Pharmacology and Toxicology: Approaches
to Measurement and Quantification, edited by Myrtle A. Davis,
2002
Ion Channel Localization: Methods and Protocols, edited by Anatoli
N. Lopatin and Colin G. Nichols, 2001
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METHODS IN PHARMACOLOGY AND TOXICOLOGY
Optimization
in Drug Discovery
In Vitro Methods
Edited by
Zhengyin Yan, PhD
Gary W. Caldwell, PhD
Johnson & Johnson Pharmaceutical Research & Development
Spring House, PA
663121118.003.png
© 2004 Humana Press Inc.
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Cover design by Patricia F. Cleary.
Production Editors: Jessica Jannicelli and Wendy Kopf.
Cover art: Figure 1 from Chapter 13, “In Vitro CYP Induction in Human Hepatocytes,” by Daniel R.
Mudra and Andrew Parkinson.
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Printed in the United States of America. 10 9 8 7 6 5 4 3 2 1
e-ISBN: 1-59259-800-5
Library of Congress Cataloging-in-Publication Data
Optimization in drug discovery : in vitro methods / edited by
Zhengyin Yan, Gary W. Caldwell.
p. ; cm. -- (Methods in pharmacology and toxicology)
Includes bibliographical references and index.
ISBN 1-58829-332-7 (alk. paper)
1. Pharmaceutical chemistry--Laboratory manuals. 2. Physical
biochemistry--Laboratory manuals. 3. Drugs--Testing--Laboratory
manuals.
[DNLM: 1. Drug Evaluation, Preclinical--methods. QV 771 O62
2004] I. Yan, Zhengyin. II. Caldwell, Gary, 1953- III. Series.
RS407.O66 2004
615'.19'0072--dc22
2004008395
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