Choi - An Introduction to Systems Biology (Humana, 2007).pdf

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Introduction to

Systems Biology

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Introduction to

Systems Biology

Edited by

Sangdun Choi, PhD

Department of Biological Sciences

Ajou University

Suwon, Korea

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© 2007 Humana Press Inc.

999 Riverview Drive, Suite 208

Totowa, New Jersey 07512

www.humanapress.com

For additional copies, pricing for bulk purchases, and/or information about other

Humana titles, contact Humana at the above address or at any of the following numbers:

Tel.: 973-256-1699; Fax: 973-256-8341, E-mail: order@humanapr.com; or visit our Website:

http://www.humanapress.com

All rights reserved.

No part of this book may be reproduced, stored in a retrieval system, or transmitted in

any form or by any means, electronic, mechanical, photocopying, microﬁlming, recording,

or otherwise without written permission from the Publisher. All articles, comments,

opinions, conclusions, or recommendations are those of the author(s), and do not

necessarily reﬂect the views of the publisher.

This publication is printed on acid-free paper.

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Transactional Reporting Service is [978-1-58829-706-8 $30.00].

10 9 8 7 6 5 4 3 2 1

Library of Congress Control Number: 2006940362

ISBN: 978-1-58829-706-8

e-ISBN: 978-1-59745-531-2

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Preface

Introduction to Systems Biology is intended to be an introductory text

for undergraduate and graduate students who are interested in com-

prehensive biological systems. Because genomics, transcriptomics, pro-

teomics, interactomics, metabolomics, phenomics, localizomics, and other

omics analyses provide enormous amounts of biological data, systematic

instruction on how to use computational methods to explain underlying

biological meanings is required to understand the complex biological

mechanisms and to build strategies for their application to biological

problems.

The book begins with an introductory section on systems biology. The

experimental omics tools are brieﬂy described in Part II. Parts III and

IV introduce the reader to challenging computational approaches that

aid in understanding biological dynamic systems. These last two parts

provide ideas for theoretical and modeling optimization in systemic bio-

logical researches by presenting most algorithms as implementations,

including the up-to-date, full range of bioinformatic programs, as well as

illustrating available successful applications.

The authors also intend to provide a broad overview of the ﬁeld using

key examples and typical approaches to experimental design (both wet-

lab and computational). The format of this book makes it a great resource

book and provides a glimpse of the state-of-the-art technologies in

systems biology. I hope that this book presents a clear and intuitive

illustration of the topics on biological systemic approaches and further

introduces ideal computational methods for the reader’s own research.

Sangdun Choi

Department of Biological Sciences,

Ajou University, Suwon, Korea

v

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